Cognitive impairments develop in response to a variety of insults to the CNS including disease, radiation exposure, or injury and constitute a significant factor with respect to overall function and quality of life. The pathogenesis of cognitive deficits is poorly understood and likely multifaceted. Our lab is focused on elucidating how injury-induced alterations in integrated stress response, innate immune response, post transcription/translational modifications, and chronic neuroinflammation affect various neural processes underlying cognitive function.